Digital Fortress Chapter 24

David Becker stood in a phone booth across the street from La Clinica de Salud Publica; he'd just been ejected for harassing patient number 104, Monsieur Cloucharde. Things were suddenly more complicated than he'd anticipated. His little favor to Strathmore-picking up some personal belongings-had turned into a scavenger hunt for some bizarre ring. He'd just called Strathmore and told him about the German tourist. The news had not been received well. After demanding the specifics, Strathmore had fallen silent for a long time. â€Å"David,† he had finally said very gravely, â€Å"finding that ring is a matter of national security. I'm leaving it in your hands. Don't fail me.† The phone had gone dead. David stood in the phone booth and sighed. He picked up the tattered Guia Telefonica and began scanning the yellow pages. â€Å"Here goes nothing,† he muttered to himself. There were only three listings for Escort Services in the directory, and he didn't have much to go on. All he knew was that the German's date had red hair, which conveniently was rare in Spain. The delirious Cloucharde had recalled the escort's name as Dewdrop. Becker cringed-Dewdrop? It sounded more like a cow than a beautiful girl. Not a good Catholic name at all; Cloucharde must have been mistaken. Becker dialed the first number. â€Å"Servicio Social de Sevilla,† a pleasant female voice answered. Becker affected his Spanish with a thick German accent. â€Å"Hola,?hablas Aleman?† â€Å"No. But I speak English† came the reply. Becker continued in broken English. â€Å"Thank you. I wondering if you to help me?† â€Å"How can we be of service?† The woman spoke slowly in an effort to aid her potential client. â€Å"Perhaps you would like an escort?† â€Å"Yes, please. Today my brother, Klaus, he has girl, very beautiful. Red hair. I want same. For tomorrow, please.† â€Å"Your brother Klaus comes here?† The voice was suddenly effervescent, like they were old friends. â€Å"Yes. He very fat. You remember him, no?† â€Å"He was here today, you say?† Becker could hear her checking the books. There would be no Klaus listed, but Becker figured clients seldom used their real names. â€Å"Hmm, I'm sorry,† she apologized. â€Å"I don't see him here. What was the girl's name your brother was with?† â€Å"Had red hair,† Becker said, avoiding the question. â€Å"Red hair?† she repeated. There was a pause. â€Å"This is Servicio Social de Sevilla. Are you sure your brother comes here?† â€Å"Sure, yes.† â€Å"Senor, we have no redheads. We have only pure Andalusian beauties.† â€Å"Red hair,† Becker repeated, feeling stupid. â€Å"I'm sorry, we have no redheads at all, but if you-â€Å" â€Å"Name is Dewdrop,† Becker blurted, feeling even stupider. The ridiculous name apparently meant nothing to the woman. She apologized, suggested Becker was confusing her with another agency, and politely hung up. Strike one. Becker frowned and dialed the next number. It connected immediately. â€Å"Buenas noches, Mujeres Espana. May I help you?† Becker launched into his same spiel, a German tourist who was willing to pay top dollar for the red-haired girl who was out with his brother today. This time the response was in polite German, but again no redheads. â€Å"Keine Rotkopfe, I'm sorry.† The woman hung up. Strike two. Becker looked down at the phone book. There was only one number left. The end of the rope already. He dialed. â€Å"Escortes Belen,† a man answered in a very slick tone. Again Becker told his story. â€Å"Si, si, senor. My name is Senor Roldan. I would be pleased to help. We have two redheads. Lovely girls.† Becker's heart leapt. â€Å"Very beautiful?† he repeated in his German accent. â€Å"Red hair?† â€Å"Yes, what is your brother's name? I will tell you who was his escort today. And we can send her to you tomorrow.† â€Å"Klaus Schmidt.† Becker blurted a name recalled from an old textbook. A long pause. â€Å"Well, sir†¦ I don't see a Klaus Schmidt on our registry, but perhaps your brother chose to be discreet-perhaps a wife at home?† He laughed inappropriately. â€Å"Yes, Klaus married. But he very fat. His wife no lie with him.† Becker rolled his eyes at himself reflected in the booth. If Susan could hear me now, he thought. â€Å"I fat and lonely too. I want lie with her. Pay lots of money.† Becker was giving an impressive performance, but he'd gone too far. Prostitution was illegal in Spain, and Senor Roldan was a careful man. He'd been burned before by Guardia officials posing as eager tourists. I want lie with her. Roldan knew it was a setup. If he said yes, he would be heavily fined and, as always, forced to provide one of his most talented escorts to the police commissioner free of charge for an entire weekend. When Roldan spoke, his voice not quite as friendly. â€Å"Sir, this is Escortes Belen. May I ask who's calling?† â€Å"Aah†¦ Sigmund Schmidt,† Becker invented weakly. â€Å"Where did you get our number?† â€Å"La Guia Telefonica-yellow pages.† â€Å"Yes, sir, that's because we are an escort service.† â€Å"Yes. I want escort.† Becker sensed something was wrong. â€Å"Sir, Escortes Belen is a service providing escorts to businessmen for luncheons and dinners. This is why we are listed in the phone book. What we do is legal. What you are looking for is a prostitute.† The word slid off his tongue like a vile disease. â€Å"But my brother†¦Ã¢â‚¬  â€Å"Sir, if your brother spent the day kissing a girl in the park, she was not one of ours. We have strict regulations about client-escort contact.† â€Å"But†¦Ã¢â‚¬  â€Å"You have us confused with someone else. We only have two redheads, Inmaculada and Rocio, and neither would allow a man to sleep with them for money. That is called prostitution, and it is illegal in Spain. Good night, sir.† â€Å"But-â€Å" CLICK. Becker swore under his breath and dropped the phone back into its cradle. Strike three. He was certain Cloucharde had said the German had hired the girl for the entire weekend. Becker stepped out of the phone booth at the intersection of Calle Salado and Avenida Asuncion. Despite the traffic, the sweet scent of Seville oranges hung all around him. It was twilight-the most romantic hour. He thought of Susan. Strathmore's words invaded his mind: Find the ring. Becker flopped miserably on a bench and pondered his next move. What move?

Did General Haig deserve to be the Butcher of the Somme?

1 July 1916, Battle of Somme started, fought by the armies of the British and French empires against the German Empire. It took place on either side of the River Somme in France, and it ended on 18 November 1916. The battle caused millions of deaths and injuries between both sides. The war changed peoples’ thinking towards war. From a great adventure, to a bloody event. General Douglas Haig was one of the commanders from the British army in the Battle of Somme, the battle with one of the highest casualties in British military history.Some people called him â€Å"Butcher Haig† or â€Å"Butcher of the Somme† after his death in 1928, because he sent thousands of British soldiers to their death. But does he deserve the title? Or was he just doing his job and was there any misunderstanding in the battle? I will talk about the evidences and explain why many people view both sides and if he deserves the title or not. The offensive (Britain & France) conceived the idea a s a battle of attrition, attacking the Germans, the aim being to drain the German forces of reserves, although territorial gain was a secondary aim.On the first day of the battle of the Somme, Commander Haig’s army (The fourth army of Britain) lost 57,470 casualties, of which 19,240 men were killed, for only one day. The French had a â€Å"complete success† which collapsed the German Defenders in south of the Albert–Bapaume road. South bank of the German defense was made incapable of resisting another attack. They retreated to the north bank which abandonment of Fricourt was ordered. The German army went to the north bank and inflicted a huge defeat on the British infantry, which killed so many Britain soldiers.A lot of people called Douglas Haig the Butcher of the Somme. Here are some pieces of evidence to support this point of view. â€Å"The biggest murderer of the lot was Haig. I’m very bitter; always have been and always will be and everybody else t hat knew him. He lived almost 50 kilometers behind the line and that’s about as near as he got. I don’t think he knew what a trench was like. And they made him an Earl and gave him  £100,000. I know what I’d have given him† (Fred Pearson, commenting on Haig in a local newspaper in 1966) Pearson was a private on the Western Front.This suggests where Haig’s position was and the opinion of the soldier in the Front line. It also tells us that General Haig received a large amount of money and an Earl given by the loyal afterward. And although there were a lot of murderer (Commanders in charge) during the war time, but Haig led a large amount of the British army to death as they called him the BIGGEST murderer. This source was written years after the war in a local newspaper called Pro Venanic.It can be trusted because it was written by a person who was in the battle who experienced what the war was like and what Haig was doing. â€Å"We were completel y exhausted. † Haig wrote, â€Å"If the war lasted, our army defeat seemed certain. † He really believed that he had won the battle. Although the Germans had lost 680,000 men during the war and had retreated 10 kilometers back from their trenches. They human cost of the Britain and French were also very high. Especially on the first day of the battle, which lost a massive number of casualties in the war history?Which made the people bitter and angry especially the anger from the men in the Front line, seeing Haig standing kilometers behind them, thinking that he was being a coward, and the ones who lost their family and relatives on the 1st of July? P. Smith was also a private in the 1st Border regiment fighting on the Somme. He was one of them who called Haig a Butcher. He wrote this in his diary, â€Å"It was pure bloody murder. Douglas Haig should have been hung, drawn and quartered for what he did on the Somme. The cream of the British manhood was shattered in less than six hours.†From this quote, we can see that this person who is angry at what Haig did in the war. He wrote this on July 1916, which was the first month of the battle of the Somme. Given that over 50 thousands soldiers died on the first day, Haig as the leader of the team, P. Smith wrote, â€Å"†¦Haig should have been hung, drawn and quarried for what he did on the Somme†¦Ã¢â‚¬  in his own diary, since the diary was only written for himself to read, he wrote down all his feelings towards the war as a soldier and this source is reliable, because no one would tell a lie in their own  private diary, and he was actually there at the battle of the Somme and he saw thousands of friends and family killed.The source supports the point that Douglas Haig is the Butcher of the battle of the Somme. â€Å"Haig was a second –rate Commander in unparalleled and unforeseen circumstances. He was not endowed with any of the elements of imagination and vision†¦ And he certainly had none of that personal magnetism which has enabled great leaders of men to inspire multitudes with courage, faith and a spirit of sacrifice†¦ He was incapable of planning vast campaigns on the scale demanded on so immense a battlefield.†This was written by David Lloyd George, British Prime Minster during the First World War, writing in his War Memoirs (1935). It gives us an idea of General Haig’s planning of war and he was incapable to be a great leader as immense a battlefield. He also describes Haig as a â€Å"second rate commander† because of the high death count at the Somme. This source is reliable because given the fact that it was written by a Prime Minister of Britain during WW1. â€Å"I want you to understand that there is a difference between a rehearsal and the real thing.There are three essential differences: first, the absence of the enemy. Now turning to the Regimental Sergeant- Major what is the second difference? † Ser geant Major. † The absence of the General, Sir. † This source was written in a cartoon from the British satirical magazine Punch (February 1917) the purpose was to make fun of the generals as we can see in the cartoon. This source is very useful for us knowing more about General Haig at the time, in the cartoon, the major general is addressing the men before an attack behind the lines.This is also reliable, because it was written in 1917, which was after the battle of the Somme. And it gives out information about Haig and his team. John Laffin, an author in modern days, wrote in his history book, British Butchers and Bunglers of World War One (2003), â€Å"Haig and other British generals must be blamed†¦ for willful blunders and wicked butchery. However stupid they might have been, however much they were the product of a system which obstructed enterprise, they knew what they were doing.There can never be forgiven. † Although Laffin earned his living taking p eople on battlefield tours and researched the war entirely from the soldiers’ standpoint, however he wasn’t in the battle, as he didn’t see what really happened and what Haig was doing at the time, he knew and heard all the things in the history by others. So this source can be either reliable or not and it might not be so fair to Haig saying that he is a butcher. On the other hand, the second interpretation is that Haig was just doing his job as a general.Different people have their different evidences for that. â€Å"The truth is that those ruddy-cheeked, bristling-mustached, heavy- jawed, frequently inarticulate generals rose to challenge after challenge, absorbed weapon after weapon into their battle-systems, and adapted themselves to constant change with astonishing success. But no one cared to make a legend out of that. † This was written by a historian named John Terraine in his Study of the Somme. â€Å"The Smoke and the Fire† in 1980.†Å"The truth is that those ruddy-cheeked, bristling-mustached, heavy- jawed, frequently inarticulate generals rose to challenge after challenge†¦Ã¢â‚¬  Terraine was talking about Haig, although Haig made a lot of success during the war, no one realized it and no one cares about it to make a legend out of that. This might be supporting the point that he was just doing his job and he made a great success in the war. A Lieutenant in the Yorkshire Light Infantry who was gassed on the Somme and invalided back to Britain, writing in a letter to the Daily Express (21st December 1916, â€Å"During the first half of the war, our leadership was flawless – perfect.There was an obvious genius for pure generalship which has made Sir Douglas Haig fit to rank with any general of past or modern times. † This source says that Haig was a flawless leader and a genius. The writer says that Haig led his team and Britain to victory and he is the hero of us. â€Å"Which has made Sir Do uglas Haig fit to rank with any general of past or modern times? † This quote tells us that Haig was one of the best Britain leaders who had quite a lot of support from the locals. This source is also reliable because it was written in December 1916, right after the war ended.The author knew what happened, although he didn’t really saw what happened in the trench. Here is a photograph showing crowds welcoming Sir Haig home from France. It was taken on 12th April 1919, a few months after the war ended. This gives us an idea that a lot of people welcoming him back and they didn’t blame him of such a massive number of death in total. They treated him as a hero of Britain who led his army to victory and saved Britain. However, this might not be such reliable as the other evidences. A photograph cannot represent the whole thing.And the photo might not be real, or it was just created by the government to raise the support to Haig. A video is more reliable then a photo because we can see the start to the end. A photo is just a capture of one single moment. There might be some other things happened in the past or later. â€Å"Blaming Haig the individual for the failings of the British war effort is putting too much of a burden of guilt on one man. Haig was the product of his time, of his upbringing, education, and training and previous military experience.One argument goes that he was, ultimately, victorious and, even if he had been replaced would there have been anyone better for the job? Even on the Somme a German officer called the battlefield ‘the muddy grave of the German army'. † This source was written by S. Warburton, in an article in the history magazine, â€Å"Hindsight†, which takes a fresh look at historical issues. The magazine was published in 1998, many years after the Battle of Somme. This source suggests reasons Haig are not a butcher and we shouldn’t blame him too much.â€Å"One argument goes that he wa s, ultimately, victorious and, even if he had been replaced would there have been anyone better for the job? † He says that Haig is a great commander at the war that no other can replace him for doing a better job. He tried his best and put a lot of effort on the planning and war, so that Britain had its victory at last. This source was written in 1998. Although the author might not be seeing the war time, it is reliable and it can be trusted that Haig was doing a great job during the war.There are more and more evidences to support both sides of opinion. They have their own point of view that we can’t say that they are right or wrong. In my own opinion, I think that General Haig deserves the title the Butcher of the Somme. He sent 50,000 Britain to death just for one day. He didn’t know what a war is like. His plan failed. Although it was the experts’ idea, but he should consider it was a good plan or not before actually doing it. He really believed that he won the battle, but in fact he did not.The Germans lost 680,000 men in the war, but at the same time, the deaths of Britain and French in total had the same amount of people died of the German empire. Haig refused requests for extra hospital trains to be made available before the attack beg. His outdated tactics led to the war being even more prolonged and unintentionally prevented a victory over the Germans. He had no idea what a real war is. He thought he was successful, but he was not. He wasn’t prepared for war, used people who were inexperienced soldiers at all.July 1 was one of the most deaths in war in the war history. He repeated the mistakes opposite of what was said organized. He is the Butcher of the Somme, I think. Overall, there is still a debate between he is a butcher or he was just doing his job. No matter which side wins, there were still a large number of people died in the Battle of the Somme. A lot of people lost their homes, and lost their family. Alth ough it was General Douglas Haig, who sent them to their death, there might be some misunderstanding in between.

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Property law - Essay Example Besides, in law the husband and wife scenario brings about the presumption of a resulting trust. However, according to the obiter of Lord Diplock in the case of petit v petit, he articulated that the resulting trust presupposition is obsolete. This view appears to be the case in regard to the Court of Appeal’s ruling in regard to Barbara’s husband, given that there is no appropriate evidence to demonstrate that this opinion can not be refuted by Barbara as would be illustrated by this application. As an alternative, the Court of Appeal has formed a prejudiced state of affairs for Barbara’s husband in regard to his position as a husband and not permitting this plead would be a violation of his human rights laid down in the European Court of Human Rights as integrated by the Human Rights Act 1998 to a just trial Article 6(1) as well as discrimination in Article 14. Barbara’s husband made a full payment for the purchase of Sunrise Lodge. This creates a scenario where he is regarded as the sole owner of Sunrise Lodge. Nevertheless, as Barbara then contributed 30% to the overall total cost makes it legally acceptable for the couples to be considered as tenants in common in regard to the given purchase money. Moreover, by the virtue of providing money to the mortgage, Barbara’s intention meets the basic principle of equity whereby the resulting trust would be presumed. Eventually, Albert sold off Sunrise Lodge and used the proceeds to make a full purchase of another freehold property, Greengables of which the legal title was placed into the joint names of Albert, Barbara and Charles. The registration of the property under the names of all the three parties gives rise to joint tenancy of both the legal and equitable estates. The position at this stage was that both the equitable and the legal estates were held jointly by Albert, Barbara and Charles for he had attained the

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Organizational Analysis on Wal-Mart - Research Paper Example The prime intention of the organization of Wal-Mart is to offer best products at lowest price so as to make its customers happy and contended. It mainly targets the customers of modest incomes rates but desiring to live a better life. Due to which, the organization expanded its operation by opening numerous stores in different countries. Wal-Mart comprises of almost 11,000 stores in more than 27 countries that helped the organization to amplify its customer base and distinctiveness in the market among others (Wal-Mart, 2014). The organization of Wal-Mart always desires to offer best quality of products to its customers in order to amplify their reliability and uniqueness in the market among many other rival players. This is done, in order to save the revenue of its target customers that may amplify its brand image and reputation. Moreover, by offering the products at a competitive price, the organization of Wal-Mart desires to enhance their life style and living standard to a significant extent. By doing so, the level of dependency and switchover costs of the customers might get reduced thereby amplifying their profitability and productivity of the organization of Wal-Mart among others. However, in order to become the leader in the segment of retailing, the organization of Wal-Mart need to offer best products at an effective price. Only then, it might become successful in amplifying its dominance and position in the market among others. But in order to fulfill the mission statement of the organization in an effective way, the human resource management offer significant concentration over certain areas such as planning, staffing, human resource development, compensation, employee relations, safety, security and risk management. This means, in order to offer best products, the organization tries to satisfy all the needs and demands of its employees effectively such as presenting

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Human Resources Management Essay Example for Free

Human Resources Management Essay On Monday, 13 January 2014, Ada wrote to Ben saying, â€Å"Please sell me your vintage BNW car for $80,000†. On Tuesday, 14 January 2014, Ben replied by leaving a message on Ada’s voicemail, â€Å"Sure, provided you pay by cash†. Ben then changed his mind and he posted a letter to Ada which read, â€Å"I have reconsidered the matter. I am no longer able to sell you my BNW†. This letter arrived on Thursday, 16 January 2014, before Ada checked her voicemail. 1) Advise Ada and Ben. There is no contract between Ada and Ben. This is because initially Ben leaves a message on Ada’s voicemail to accept the offer. However, Ben changes his mind and posts the letter to Ada on the same day, but the letter arrived before Ada checked her voicemail. Although the voicemail was sent earlier than the letter, acceptance can only be made with actual communication and notification to the offeror. Besides, according to the postal rule, the acceptance is deemed to be competed when the properly stamped and addressed letter of acceptance is posted, and not when it is delivered to the offerors’ address, or received by them, or brought to their notice, or read by them.1 This rule, laid down in Adam v. Lindsell in 1818. It explained that if the defendants were not bound by their offer when accepted by the plaintiffs till the answer was received, then the plaintiffs ought not to be bound till after they had received the notification that the defendants had received their a nswer and assented to it.2 In this case, the contract be only be made unless Ada checks her voicemail before the letter arrived. Therefore, Ada does not have any legal claim against Ben. 2) What difference, if any, would it make if: a) Ben’s letter had never arrived; There is no contract between Ada and Ben if Ada never checks her voicemail. This is because the postal rule does not apply to situations where the acceptance of an offer is communicated by any instantaneous methods such as telex, telephone and fax. The rule with regard to acceptance by such methods is that the contract is complete only when the acceptance is received by the offeror.3 Therefore, the contract only takes effect when it is received and read by Ada. On the other hand, there is a binding contract between Ada and Ben if Ada has knowledge of the acceptance by Ben. The contract comes into existence as soon as Ada checks the voicemail. With reference to the case of Entores Ltd v. Miles Far East Corporation in 1955, the plaintiff in London sent a telex to the defendant in Amsterdam offering to buy goods from the defendant. The defendant sent a telex in return to the plaintiff accepting the offer. Therefore, a contract was made between the parties when the defendant’s acceptance was accepted by the plaintiff.4 b) Because of a fault on Ada’s voicemail system, Ben’s message had not been recorded; There is no contract between Ben and Ada. This is because Ben’s message has not been recorded, so Ada does not receive and read the message. Since there cannot be acceptance of an offer without the knowledge of it, acceptance must be communicated to the offer, and mere inactivity or silence on the offeree does not create a contract as well. The rule laid down in Felthouse v. Bindley that mere inactivity or silence cannot amount to an acceptance is correct in 1862. The plaintiff offered to buy a horse from his nephew, John, who was going to sell it by auction. John intended to accept his uncle’s offer and advised the auctioneer to reserve the horse for his uncle. However, the nephew did not send his acceptance to the plaintiff and finally the horse was sold by the auctioneer by mistake. However, since John had not communicated his acceptance to the plaintiff, there was no contract between them.5 In the case of Ada and Ben, Ben also sends a letter to reject the Ada’s offer  after he has changed his mind. The rejection of an offer by the offeree kills the offer. The offer comes to an end. It can no longer be accepted by the offeree.6 Therefore, a contract cannot come into existence. c) On Sunday, 12 January, Ben had asked Ada if she wanted to buy his BNW? There is an invitation to treat if Ben has asked Ada to buy his BNW. It is not an offer because Ben just invites offer rather than making one. Where Ada accepts the terms of the invitation, she makes an offer but there is still no contract. Ben is still free to accept or reject the offer. With reference to the case of HKSAR v. Wan Hon Sik in 2001, the display of pirated video discs on the shelves of the shop was just an invitation to treat. A customer who selected the goods from shelves and took them to the casher’s desk only made an offer. There was no sale at that point. The contract was not completed until the owner of the shop accepted the offer.7 Therefore, an invitation to treat is different from an offer. In the case of Ada and Ben, since Ada makes an offer which can be accepted or rejected by Ben. No contract has been concluded between them because Ben rejects the offer by sending a letter that is arrived before Ada checks her voicemail.

Menigitis research paper Essay Example for Free

Menigitis research paper Essay Meningitis is a bacterial infection of the membranes covering the brain and spinal cord. A family who lived in Geneva, Switzerland was first diagnosed with the disease in 1805. It was not until 1866, that the disease traveled its way into the United States. Professor Anton Weichselbaum discovered the cause of cerebro-spinal meningitis illness in 1887. There are five types of meningitis: bacterial meningitis, viral meningitis, parasitic meningitis, fungal meningitis, and non-infectious meningitis. Bacterial meningitis and Viral meningitis are the two most common and serious types of meningitis. Bacteria meningitis is caused by bacteria. There are several types of pathogens that can cause bacterial meningitis: Haemophilus influenzae, Streptococcus pneumoniae, and Listeria monocytogenes. Some of the symptoms of Bacteria meningitis are nausea, vomiting, increased sensitivity to light, and confusion. Bacteria meningitis can be life threatening and result in the need of medical attention. It is also contagious and can be treated with antibiotics. Viral meningitis is more common, than Bacterial meningitis and is sometimes referred to as â€Å"aseptic meningitis.† Viruses, like enteroviruses and herpes simplex viruses, cause viral meningitis. Viral meningitis occurs mostly in children younger than the age of five. The most common cause of viral meningitis is enteroviruses, which is most often spread from person to person through fecal contamination. There is no specific treatment for Viral meningitis. It is just like any other virus, it runs its course for about 7 to 10 days. To prevent from getting Viral meningitis, you should wash your hands thoroughly, especially after changing diapers and using the bathroom, and avoid sharing items with sick people or when you are sick, such as eating utensils. Both bacterial and viral meningitis show similar signs and symptoms, but bacterial meningitis is more severe and fatal. There are vaccines for some of the types of bacteria that cause bacterial meningitis. There are no vaccines for the most common cause of viral meningitis, so the best way to prevent it is to not get a viral infection. Works Cited Page 1. 2.http://www.ehow.com/about_5234584_meningitis-first-discovered_.html 2. 3.http://www.medicalnewstoday.com/articles/9276.php 3. 4.http://www.news-medical.net/health/History-of-Meningitis.aspx 4. 5.http://www.meningitis-trust.org/meningitis-info/types-and-causes/ 5. 6.http://www.cdc.gov/meningitis/index.html 6. 7.http://www.nmaus.org/meningitis/viral-or-bacterial.htm

Optically Active Pharmaceutical Compounds Biology Essay

Optically Active Pharmaceutical Compounds Biology Essay The molecules which are non super imposable mirror images of one another are termed as chiral. These are a pair of enantiomers and are diasymmetric as well as optically active. Since they promote optical rotation, these enantiomers are also known as optical isomers. These chiral molecules consist of a tetrahedral carbon atom which is attached to four different groups. The carbon atom is the stereogenic or the asymmetric centre of the molecule. The enantiomers are similar in their physical and chemical properties in an achiral environment. Enantiomers have different biological properties. This influences the efficacy and the toxicity of the compounds. Usually, one of the enantiomers is bioactive and the others may be inactive or toxic. Example, Verapamil is a calcium channel blocker used for the treatment for blood pressure, angina. The (S) isomer treats the increase in BP more effectively than the racemate form. The (R) isoform inhibits resistance of cancer cells to anti cancer drugs (Crosby, 1991). The enantiomerically pure compounds are very useful and vital in the pharmaceutical and agrochemical industries. It has also been shown that the optically pure and chiral compounds should be used rather than mixture of enantiomers. The optically active pure compounds are used to produce antibodies, hormones, anti inflammatory, amino acids, vitamins, anti cancer drugs, cardiovascular drugs. Chiral chromatography or ligand exchange chromatography was an analytical technique used for separating enantiomers. High performance liquid chromatography whereby chiral stationary phase is used was efficient in separation of enantiomers. The optically active ligands like amino acids are bound covalently to a solid support, thereby forming a chiral stationary phase. Various amino acid derivatives like N -(3,5-dinitrobenzoyl) phenyl glycines are also used.(Pirkle and Pochapsky,1987). The major advantage of chromatography is that it results in high enantiomeric excess and is suitable on the analytical scale. However, its drawback is that the scale up is difficult. The production of enantiomers for optically active drugs may be produced by different methods. Pure compounds are recovered by various extraction techniques from chiral compounds (alkaloids, carbohydrates) exist as pure enantiomers naturally. Fermentation of cheap substrates which are available in abundance (like molasses and sucrose) was a widely used source of single chiral molecules lactic, tartaric and L- amino acids and also for complex substances which include vitamins, antibiotics and hormones.(Buchta,1983). Optically pure compounds may be prepared from inactive starting materials by asymmetric synthesis and resolution of racemates. In the process of asymmetric synthesis (Stinson,1993) an enantiomeric reagent or catalyst is used for carrying out a specific reaction on an achiral substrate (prochiral) to produce a single chiral product. Overall, it is a selective technique as it leads to product selectivity. Its disadvantages are that it may be expensive due to the numerous steps involved and also because of the use of costly enantiomeric reagents. It is cheaper to produce a racemic mixture and then separate the enantiomers by physical methods like kinetic resolution or diastereomeric crystallization. Covalent derivatives are formed using optically pure resolving agents in the diastereomic crystallization method. The drawback is that it is wasteful since the unwanted isomer may be discarded. On the other hand, kinetic resolution is based on the principle that two enantiomers react at vari able rates in the presence of a chiral catalyst like an enzyme. This method involves product selectivity. Biotransformation has also become a key technology used to produce chiral substances. It was used by many companies Eg. Celgene Corporation developed procedures to produce amines by using amino transferase (Celgene corporation,1990).The main advantage of this procedure is that it allows 100% theoretical conversion of the substrate into the final product. Membrane chirotechnology is also a widely used method for producing optically pure isomers. In this procedure, the membrane itself maybe intrinsically enantioselective. This means that the membrane represents a chiral system that separates the desired isomers on the basis of spatial conformation. On the other hand, a membrane separation process may be combined with kinetic resolution by making use of an enantiospecific biocatalyst.That is, the membrane helps in the separation of the product from the substrate on the basis of their chemical properties like solubility. Enantiospecific catalytic membrane reactors may also be used. These comprise of membrane processes which are advantageous as they have the ability to work in a continuous mode and enormous amounts of material could be processes at once. The competitive production of chiral substances requires a large scale, cheap process for the production and separation of the enantiomers. Eg. Pyridoxal phosphate dependant lyase and transferase were used as catalyst in the synthesis of L- amino acid via the carbon carbon bond formation. (Sheldon,1993) The widely used enantiospecific membrane reactors are ultrafiltration hollow fibre membrane reactor (Responsible for production of L phenylalanine by using dehydrogenase catalyst (Schimdt et al, 1987) ) immobilized enzyme membrane reactor, packed bed continuous bioreactor, biphasic membrane reactor etc. Ultra filtration, electrodialysis and membrane extraction are common separation processes that are combined with biotransformation. Matson and Quinn(1979) showed the optimization in production of amino acids enantiomers and studied the separation of L amino acids from the racemate solution by making use of an impregnated liquid membrane alone with an enzyme immobilised membrane. Production of L-phenylalanine from racemic mixture of D,L phenyl lactate was shown by 2 consecutive biotransformation in an enzyme membrane reactor whereby the enzyme and cofactor(NAD/H) had been compartmentalised behind an ultra filtration membrane.(Schmidt et al, 1987). Intrinsically enantioselective membranes are also widely used. Substances which are optically active can be separated on the basis of there physical stereo selectivity. Polymeric membranes having the enantioselective properties intrinsically may be prepared making use of chiral polymers or by chiral modifications of the achiral porous membrane in the presence of chiral recognition agent like cyclodextrins, cyclophane and oligopeptides. In order to prepare the enantioselective membranes, optically active polyacryl amides and cellulose derivatives may be used. Yoshikawa et al,1996, showed separation of tryptophan, phenylalanine and alanine by ultra filtration using the chiral selector which was molecularly imprinted polymeric membranes(DIDE derivatives). Enzymes have the ability to catalyse a broad spectrum of chemical reactions with great efficiency and selectivity under mild and environmentally friendly conditions. By exploiting the selectivity of enzymes for one form of the enantiomer of a racemic mixture, the enantiomerically enriched compound can be obtained by biocatalytic resolution.(Thomas et al,2002) Most commonly, the hydrolytic enzyme are used since they display a range of advantages like stability, specificity, no requirement of cofactors. Among hydrolases, lipase is most commonly used because of high enantioselectivity, commercial availability and good stability in various media.(Seung Hwan et al,2004) Recently a new technique was introduced to display the peptides and proteins on the surface of gram negative and gram positive bacteria, yeast or mammalian cells. This was done by fusing the peptides to surface anchoring motif; and the technique is known as cell surface display. The cell surface display lipase proved to be an excellent biocatalytic system for the kinetic chiral resolution of the racemic compound. Recent advances have shown the use of enzymes in the synthesis of optically pure drugs and biologically active compounds. Enzymes have the ability to distinguish between the enantiomers of racemic substrates. Various strategies have been developed to improve the stereoselectivity of resolutions catalysed by the enzyme. This includes modification of the substrate, recycling of the product and altering the reaction conditions. By making use of these strategies, enzymes with modest stereoselectivity can also be used but only one enantiomer is produced with high yield. Enzyme can catalyse transformations with high region selectivity and chemo selectivity under mild reactions. This is important in the modification of chiral drugs. Eg. Penicillin acylase causes the hydrolysis of benzyl penicillin without affecting the beta lactam ring and allows the industrial preparation of 6-aminopenicillanic acid which is a precursor for many semi synthetic penicillins. Enzymes (hydrolases) have success fully been used in the synthesis of chiral pharmaceuticals, however modern methods of protein engineering and industrial microbiology help in the production of enzymes which are more inexpensive, stable with broad substrate specificity and high stereoselectivity.(Alexey L.Margolin,1993) Catalytic asymmetric synthesis is the asymmetric synthesis that is catalysed by chiral (transition) metal complex. The reactions that are involved are Redox transformations or carbon carbon bond forming processes that complement enzymatic hydrolytic process. The three types of chemo catalysts that exist are heterogenous metal catalyst, homogenous complex and soluble chiral acid or bases. Emil Fishers work on asymmetric induction which was based on cyanohydrin synthesis was the first reaction subjected to asymmetric catalysis. Enantiomerically pure amino acids, amino alcohols, amines, alcohols and epoxides play an important role as intermediates in the agrochemical and pharmaceutical industry whereby high level of purity and a large quantity is required. The enantiomerically pure active compounds help in improving the economics of the process, thereby leading to reduced quantities applied and less amount of an environmental impact. Chemical process for the manufacturing of amino acids: Even though asymmetric syntheses of amino acids are known (Michael Breuer et al,2004), no economical process has been developed. Bucherer Bergs sub type which is Strecker synthesis was employed for the industrial manufacturing of the racemic amino acids. The alpha amino nitrile is produced from hydrocyanic acid, ammonia and an aldehyde and may be hydrolysed to the amino acid directly or in the presence of carbon dioxide it gets converted into hydantoin. The hydantoin is then subjected to hydrolysis in a basic media to give the racemic amino acid. Another route to the racemic amino acid is amido carbonylation in the presence of a transition metal. Although, there is no commercially viable chemical process for the synthesis of enantiomerically pure amino acid, the production of racemic amino acid is still of great importance because the racemates may be converted to enantiomerically pure compounds by various biocatalytic methods. The catalysts used in the biotransformation are metabolically inactive cells or isolated enzymes. It is the method of choice for the production of enantiomerically pure D- amino acids and various other non natural amino acids. Lyases may be used as biocatalysts in the production of L- Aspartic acid from fumaric acid (Beller et al,2000). Amino acid dehydrogenase (deaminating amino acid oxido reductase) allows enantioselective biotransformation on an industrial scale. These enzymes have low substrate specificity due to which non natural compounds may also be transformed. In addition, they also require co substrates which help in supplying the hydride ions for the reduction of Schiff base. There is also a chemo enzymatic method for amino acid synthesis. In this, L- amino acid gets oxidised by L- amino acid oxidase. Imine (intermediate) gets reduced by Pd-C in ammonium formate buffer. In the resulting racemic mixture, only L enantiomer is utilised by oxidase where as the D- enantiomer accumulates. Therefore, the enantiomeric form of the amino acid which is produced depends entirely on the specificity of the oxidase. The enantiomerically pure amino acid can also be prepared by the racemate resolution. Eg: L and D amino acid can be prepared with the Hydantoinase-carbamoylase system. Production of carboxylic acids: Carboxylic acid can be isolated from natural sources(chiral pool).Naturally occurring chiral compounds obtained from the chiral pool are an alternative to the synthesis of enantiomerically pure products. An examples of a chiral carboxylic acid that is isolated from the natural sources is L (+) tartaric acid (Mitsugi et al,1978). During the fermentation of grape, the isomeric form of tartaric acid separates out as tartarate (potassium hydrogen tartarate).On reacting with calcium chloride or calcium hydroxide and sulphuric acid, isomeric tartaric acid is released; gypsum and yeast residues occur as the by products. Natural carbohydrate building blocks were used for several decades for the preparation of sugar acids which were enantiomerically pure. Another method is the classical chemical synthesis which involves crystallization with enantiomerically pure amines. The enantiomers of the racemic carboxylic acids are known to separate by fractional crystal lization of the diastereomeric salts which are formed with the enantiomerically pure amines. Eg: Thiazolidine carboxylic acid (enantiomerically pure), an intermediate in the synthesis of CP-060- S is isolated by the resolution of racemate with N- benzyl-1-phenylethylamine. (Pompejus et al, 2001) Production of amines: The chemical process involved is the crystallization with chiral carboxylic acids. Isolation of enantiomerically pure amines can be carried out by the crystallization of diastereomeric salts of chiral carboxylic acids with chiral amines (Jacques et al,1980). Thus (R) or (S) 1- phenylethlyamine may be produced on an industrial scale by the crystallization with either (R)- mandelic acid or (S)- malic acid. Mandelic acid was shown to be an important resolving agent for numerous numbers of amines. Dutch resolution is a variant of the classical racemate resolution. In order to reduce the search for an appropriate resolving agent for an amine through combinatorial approach, a mixture of many optically active acids were used. The salt that was precipitated contained several acid anions. Production of optically active amino alcohols: (S)-2-Aminobutanol is an important amino alcohol intermediate which is used for the synthesis of ethambutol (tuberculostatic)and it must be administered in its enantiomerically pure form as it may lead to blindness. The enantiomerically pure form can be obtained from the racemate by carrying out the crystallization with L-Tartaric acid.(Sheldon et al,1993) Production of alcohols: The main process involved was the asymmetric hydrogenation of ketones. Noyori et al showed the development of asymmetric hydrogenation of keto esters and ketones. The catalysts used were ruthenium complexes of binap and derivatives like tol-binap (Akutagawa,1995)and segphos. The biotechnological process is mainly the enzyme catalysed resolution. For the resolution of racemate alcohols, enzymatic acylations were developed in early 1980s.The racemic alcohols are made to react with an acylating agent under enzyme catalysis whereby one enantiomer is unconverted whereas the other enantiomer is esterified. The biocatalysts used are bacterial and fungal lipases. Production of epoxides: This includes sharpless asymmetric dihydroxylation. The route to the formation of chiral epoxides is based on the optically active diols which may be converted to their respective oxiranes. Another method is the Jacobsen asymmetric epoxidation which is based on (salen) manganese III precatalyst and the hypochlorite is used as the stoichiometric oxidizing agent. The chemical processes may be compared with the biotransformation with respect to the environmental impact and economic efficiency. The drawbacks of the chemical routes are solvent emission or toxicity of certain compounds. On the other hand, chiral technologies are developing rapidly. Highly versatile technologies and procedures are introduced. Most chiral intermediates are produced in minute quantities. Therefore, the criteria that should be considered for the methods introduced are that they should have a broad substrate spectrum, not require specialised equipment and have a cost effective access to a range of products. It is not possible to make general conclusions about the superiority of one type of technology in comparison with the others. The most economic technique will depend on their component which is why each case should be investigated individually. However, in the overall process, the chiral step should be introduced as early as possible but this may be hindered by other factors like racemisation of the unwanted isomer. Membrane chirotechnology is also an emerging technique having several advantages with respect to the purity of simple isomers, productivity and ease of scale up. These techniques have mainly been used at the laboratory scale. Application on a large scale needs more investment especially in developing the experimental set up rather than investigations which have been carried out on chirality that have been developed in the chromatographic field.

The First Crusades Essay -- Religious History

The principals of human nature force people to fight for what they believe in; therefore, defending religion is not objective to that principle in the case of the crusades. In the case of the First Crrusade many people did just that, volunteered knowing that many of them would die defending their religious beliefs. In the days of the Byzantine Empire, a person’s faith or religion determined how they would live their life. It is the nature of people to fight for what they believe in; therefore, defending ones religion is not objective to that principle as in the First Crusade. A crusade is characterized as any of the military expeditions undertaken by Christian powers in the 11th, 12th, and 13th centuries to win the Holy Land from Muslims. The First Crusade played a vital role in Late Antiquity (Middle Ages) Europe; consequently, setting the stage for future events in European history and the preface for the Crusades to follow. The reason for the initiation of the First Crusad e, how it was fought and who were involved, notable battles and generals, and how upon its finale it reshaped the Byzantine Empire. The conquest to pursue war against Sejul Turks, who were Sunni Muslims, began when Crusaders realized the Jerusalem had not been under Christian control in 461 years. This was shocking because Christianity has spread throughout Europe, Africa, and the Middle East in Late Antiquity. After Muslims captured Jerusalem in 1076, any Christian who wanted to pay a visit to the city of Jerusalem faced many obstacles because Muslim soldiers made it very dangerous for them to do so. Jerusalem is very important to Christians because it has lots of biblical references. In Europe the Pope along with the Papacy has assumed the power of utili... ...rs rightfully thought belonged to them. For this reason the fighting of the First Crusade can be viewed as the war that started all Christian Religious wars or Crusaders that followed. It ended as a time changing journey that changed the Byzantine Empire and the reasons wars were fought. The First Crusade made it possible to start wars with anyone for their religion throughout Europe across the Mediterranean to Asia, on to Africa, and other surrounding areas. The advances of the Crusaders can be seen as admirable and condoned in the eyes of God, who was the only entity that Crusaders deemed worth possessing the power to judge them. Works Cited http://www.fordham.edu/halsall/source/urban2-5vers/htm http://www.deremilitari.org/resources/articles/magdalino.htm http://www.historylearningsite.co.uk/cru2.htm http://en.wikipedia.org/wiki/First_Crusade

Relationships :: essays research papers

Relationships are impossible, or are they? Why is it that most relationships don’t work? Man meets woman, they date, move in together, get married, have kids and then divorce. This is what most relationships are nowadays. What causes a relationship to fall apart, what relationships you should get out of and are there such things as soul mates. Most people believe that their relationship isn’t like others. They don’t have problems. These kinds of people also think that their partner won’t cheat on them or do anything wrong. But the truth is that almost all relationships won’t last forever. A few reasons relationships fall apart are if one partner cheats, they lose interest in each other, lack of communication which causes problems, if you try to change someone and it backfires, and if you hide something you should have told the other person and then they find out about it later. In a relationship you can tell when you’re losing interest in each other. Some signs are that you don’t talk much with each other, you don’t spend time together anymore instead its spent with your friends away from home. Some signs to tell if the other person in the relationship is cheating is by the person starts to come home from work later then they usually do, they start to smell like perfume that neither of you have, when you confront them about cheating they get all nervous and deny it, when you ask them why they’ve been coming home late from work lately they makeup stupid excuses. And they say there going somewhere but when you phone to see if they are there they aren’t. If you’re in a relationship and the person does any of these things your relationship could be falling apart. Should you leave or stay in an abusive relationship? The answer to this question as you should know it is leave as soon as you can. The reason you should leave an abusive relationship is because if you don’t, you could end up hurt. Most of the time when a person is in this kind of a position they are too scared to leave it because they think the one who is abusing will hurt them more. In some cases they could that’s why its important to leave. Another thing about people who are in this position is that if you suspect they are being abused and you confront them about it they will deny it and change the subject. A few other signs of someone being abused is if they always

Macro Effects of massive Earthquake

The earthquake also caused a high tsunami which breached the safety of nuclear plants in Fukushima prefecture. What is worse, though, is it caused a partial meltdown, and now Japanese citizens not only suffered by damage of earthquake itself but also the dangerous level of radiation from the plants. On June 10th 2013, a Japanese National Police Agency announced there were 1 5,883 confirmed deaths, 6,145 injured, and 2,671 people missing, as well as 126,458 buildings totally collapsed, with a further 272,191 buildings ‘half collapsed', and another 741,684 buildings partially damaged(â€Å"Countermeasures†).This is the largest economic shock for the Japanese economy since the end of World War II. It may take some time before the full economic impact of the earthquake is known, but we can still look at the scale of earthquake economically by comparing it with the Great Hanshin-AwaJi Earthquake of 19951 in Japan and how it affected on the economy. Thesis: The Earthquake's Im pacts on Economic Flow and Stocks There are two important points to consider concerning the impact of this catastrophe: flow and stock. Flow is economic activities in everyday life, such as spending, production, income, and many other economic rowths.Stock is a concept representing the abundance at some point in time, such as housing, factories, and social capital and so on. The flow of economic activities was damaged by the earthquake and tsunami. First of all, the earthquake and tsunami caused an impediment in physical economic activities such as production and consumption in the disaster area. Next, they cut off the distribution to the disaster area, and the connection between products and point of consumption was no longer smooth. Thirdly, it affected consumers psychologically.Less people spent money for entertainment and leisure, and the economy xperienced a sharp downturn in consumption. At the time of the Great Hanshin- Awaji Earthquake, the consumption and production activit ies fell immediately after the earthquake, but the economy slowly recovered which is mentioned later at the Impact on Japanese Macro Economy. In comparison, the Great East Japan Earthquake and Tsunami is larger than the Great Hanshin-AwaJi Earthquake, and it caused nuclear power plant accident which caused serious radiation problem and the huge power outages.It got goes worse and worse, and it will have a quite long effect on its economy. The earthquake and tsunami also caused a large loss of stocks. Stocks that about 102. 31 billion US dollars. This was equivalent to 0. 8% of the stock of the whole country. Compares to the Great East Japan earthquake and Tsunami, the loss amount is much greater than the scale of the Great Hanshin-AwaJi Earthquake. It caused crucial widespread damage on coastal areas in eastern Japan. Japan Cabinet Office estimated the loss was approximately 173 billion dollars, and it is still not completely determined yet (â€Å"Economic Basic Data†).Impact on Japanese Macro Economy In response to the earthquake, Japan's economy was confused; there was a sharp ecline of production activities, decline of exports, and self-restraint of consumption. Japanese macro economy recorded a big decline after the earthquake. The real GDP growth rate in first quarter of 2011 declined 0. 9%, and second quarter in 2011 for 0. 5% decrease. In the case of the Great Hanshin-AwaJi Earthquake of 1995, on the other hand, there was a slight increase of about 0. 009% in first quarter of 1995.It was backed by strong yen, and the real GDP growth rate had an upward trend until first quarter of 1997. Even Hyogo Prefecture which was worst disaster area, showed a apid recovery as early as the second quarter of 1997. It is back up to 0. 04% growth (â€Å"Economic Basic Date†). If one takes the Japanese economic growth from 1995 into account, the Great East Japan Earthquake was worse than the Great Hanshin-AwaJi Earthquake. Antithesis However, there are some researchers who propose the positive effects from the disaster by economic points of view.The Japanese Society of Psychiatry and Neurology published there is a decline in suicide in disaster area. In Yamagata- prefecture, one of large damaged area from the earthquake had recorded 43 ecreases on suicidal case in 2011. It recorded there were less than 300 cases of suicide in the prefecture since 1998(â€Å"The Decline in Northeastern Japan Suicide Rate after the Earthquake†). In addition, the Ministry of Health, Labour and Welfare also published that the rate of suicide is significantly decreasing nation-wide.It decreased 1039 total suicide cases in 2011(â€Å"Suicide Measures†). It explained suicide rate is strongly linked to economic figures, and there was a Job increase in the waste disposal business and construction industry with the reconstruction budget injection. It will enhance the economy and thus leads to a decrease in the suicide rate. Furthermore, the earthq uake had an effect on the aging population in Japan. To begin with, there was a high rate of elderly population in the area which had devastating damage by the earthquake and tsunami.For instance, there were towns called Otsuchi and Yamada that had over 40% of the population was people over 60 years old, and 30% by elderly people (â€Å"Estimated Future Population of Japanese Municipalities†). Japan has a huge aging problem, and it is estimated that the elderly will make up one third of the Japanese population in 2030. A relatively large number of elderly people were victims of the disaster, and the decrease of the amount of the aging population ease aging problem although it will Just have effect a short term on its demographic figure overall (Kouno).Synthesis Next, I will diagnose the macro-interaction to the earthquake with Japanese disaster mitigation policy. The Japanese government takes mitigation policies to recover the economic crisis caused by The Great East Japan Ea rthquake and Tsunami. First, they put large capital investment in its economy after the disaster. The Central Bank of ncluding quantitative easing and qualitative easing, which aims to break away from deflation. In addition, they claim there is no need to change the targeted inflation rate of 2%, which was the target set before the earthquake.The Central Bank of Japan was also indicated that they will implement Open-End type2 for government bond and eliminate the three years restriction for payback period for its bond (â€Å"Four Major Policy†) Second, the Japanese government tries to break away from deflation and encourage weak yen. In order to stimulate the recovery of production and anufacturing, and to support active economic activity, Japan is resuming the nuclear power plant gradually with new enhanced safety standards.This will be the basis for favorable production conditions in Japan. Japanese Prime minister Shinzo Abe takes a new policy of trade promotion and is tryi ng to enhance the competitive position of Japan's export-driven economy in international markets. A Weak yen is the direct way to enhance the export driven economy though Japanese trade is still in the difficult situation. There is a deterioration of the trade balance, and it has experienced decrease on current account surplus three months in a row.However, because the government sent the clear message of weak yen to the market, Japanese yen becomes cheaper in the past three and a half years. They anticipate the improvement on export. Conclusion In conclusion, the Great East Japan Earthquake and Tsunami wreaked enormous damage on Japanese economy. Even though some positive effects were followed by the disaster as some researchers advocated, they have an insignificant effect on the economy because of its tremendous damages which is considered to be one of the top five largest earthquakes in the world.Because it did not only inflict damages to ives and properties but also caused cruci al damages to major nuclear plant stations, this is the most difficult crisis Japan has ever faced after World War II. From my perspective, Japanese government needs to have a more effective growth strategy to increase productivity since the workforce is decreasing. It needs to enhance efficient flow for workforce and capital. For instance, ease the regulation restriction for the workforce, and encourage the diversification on human resources. It is significant that government help to reform the active business activities for Japanese economy recovery.

Nursing Students at any College

Considering a nursing career can be both challenging and at the same time rewarding.   It is a commitment that needs time and effort in order to help others while constantly studying to update their knowledge.   Nursing is not for everyone, it is for the elite.   Even though it is a trend it does not mean everyone can pursue the career.   For students who are in this field it has never occurred that someone took it so lightly.   The pressure is always there yet they need to put a smile on their faces in front of their patients no matter how hard it is to work and study at the same time. One student in a prestigious school is at his third year.   He knew it along that he was going to pursue a nursing career.   He has his mind-set since he was a kid and now only a year to go before he graduates.   Although he wanted to be a nurse, he could not deny the fact that stress is the main hindrance to his goal. On the other hand another student from a different school is at his fourth and final year in nursing.   At first he never wanted to be a nurse, thinking that it would be hard to care for someone he barely knows.   After the span of four years he realized that everything was a misconception.   It is not just the hard work.   It is the feeling of fulfillment when he sees his patient go out of the hospital thanking him for the care that he has given. After interacting with some students, I realized that nursing is not a walk in the park career.   Nursing is not as simple as caring it requires knowledge and grace while performing a task. Stress is always present in any job.   Nursing is a good example of a very stressful career.  Ã‚   It is never a sedentary job that requires time and energy while performing your job.   Even as student, they are trained under pressure.   Every nursing student cares for their patients while thinking about their report which is one of the scenarios of stress in any student taking up this course. It is admirable to see students managing their time.   They tend to think about their priorities than having fun with their peers.   During weekends, there are times that they don’t even have a break.   Somehow they have to go to the hospital during weekends to get their patient’s data before their exposure in the hospital the following day. The profession is based on taking care of other people but it is very important to take care of your own well-being.   One awry of students is that they think more about their patients and they forget about themselves.   It is essential to be vigilant on personal health.   You need to take good care of yourself before you can take care of others. Learning is constant in this career.   There are always new updates of the old concepts that every student should be aware of.   Books are not just the source of information these days.   With the theoretical knowledge a student is equipped with the know how in applying it in the field. One of the most important aspects of nursing is teamwork.   Collaborating with the co-nurses is a must in maximizing the treatment for each patient.   Planning with the team can result to lesser effort and more effective intervention. Even as student nurses, they are considered as modern day heroes.   But as humans there are also limits.   It is very important to know your limitations, students should never intervene with the duties that only a registered nurse can do.   Instead of helping they might end up making the situation worse. References Antai-Otong, Deborah (2003). Psychiatric Nursing, Biological and Behavioral Concepts . Singapore: Thomson Asian Edition C. Dailing, Personal Communication, July 28, 2007 M. Sharks, Personal Communication, July 29, 2007            

Marigolds

What change does the main character experience from the beginning of the story to the end? From the beginning to the end of the story, the main character experiences her time when she was changing from child to woman. Growing up during the Great Depression in impoverished rural of Maryland, her family had been living through poverty and financial struggles.She was fourteen going on fifteen by that time so she understood everything her family or her neighbors had been through. But She and ere brother were so young and innocence that they liked running around and teasing Miss Little with her marigolds mounds that she planted every summer. And the rising action that changed her childhood was the midnight when she first heard a man that was her father cry in helplessness and hopeless because he couldn't get a job and take good care of the family.She felt his despair and her emotion of crying In fear, and degradation that led her run and ruin all the marigolds of Miss Little. When she loo ked up to â€Å"stared at her†, † that was the moment when childhood faded and manhood began†. She felt guilty, â€Å"awkward and ashamed† that moment marked the end of Innocence. Why did Miss Little plant the marigolds? She planted the marigolds because that was her happiness. They were very bright and colorful compared to her â€Å"sorry gray house†.Those passionate yellow mounds made her house really stand out. She took care of them â€Å"all summer, every summer† as her one Joy and hope. Without reviewing the story, what descriptive details do you remember? The detail that stands out In my mind Is the scene Elizabethan father cried out loud† In the middle of the night because he felt Impotent for not do anything for his wife and his kids In twenty-two years. A man Is always the leader of the house. Taking a good care of his family Is the most Important role they should.He was a strong man † who could whisk a child upon his shou lders and go singing through the house†. And † he sobbed, loudly and painfully, and cried helplessly and hopelessly In the dark night. † This really touches my heart. For the first time he despaired, and behind the wall, that also was the first time his daughter hear him cry. Marigolds By emphysema K. Kennedy job and take good care of the family. She felt his despair and her emotion of crying in the end of innocence.Why did Miss Little plant the marigolds? Remember? The detail that stands out in my mind is the scene Elizabethan father â€Å"cried out loud† in the middle of the night because he felt impotent for not do anything for his wife and his kids in twenty-two years. A man is always the leader of the house. Taking a good care of his family is the most important role they should. He hopelessly in the dark night. † This really touches my heart. For the first time he

Miguel Hidalgo y Costilla

Miguel Hidalgo y Costilla was born on May 8th, 1753 to Cristobal Hidalgo y Costilla and Ana Maria Gallaga near Penjamo, Guanajuato. He was considered a Criollo or Mexican of Spanish descent that had been born in the New World. He was a very intelligent man who knew several languages, read French literature and wrote texts in Aztec. In 1773 Hidalgo y Castillo received his bachelor’s degree in theology from the Colegia San Nicolas in Valltolid. He was ordained in 1778 and became the priest for the village of Dolores, Guanajuato in 1803. Father Miguel Hidalgo y Costilla was an unusual priest. Contrary to Church doctrine, Hidalgo y Costilla was known to gamble, dance, challenge the papacy of Rome and keep a mistress. He was also known to speak out against the king of Spain. In 1803, when Hidalgo y Costilla was the priest of Dolores, his house was a well known gathering place. It was the equality in the house that drew people, with poor Indians and castes socializing with Spanish and criollos.  Ã‚   Current events and literary topics were frequently debated, but Hidalgo's orientation grew more scientific as time passed. He was not so interested in literary cultural enlightenment, and was more concerned with the development of social consciousness and economic awareness.   (Hamill 82) Hidalgo y Costilla was very interested in developing Dolores’s ability to be economically self sufficient. Colonists were prohibited from producing many different types of commodities and this made its difficult, if not impossible, for the colonists to become self supporting. Two of these were wine and silkworms, both of which Hidalgo y Costilla encouraged. With the French seizure of Spain in 1808, the imposition of Joseph Bonaparte on the throne, and the creation of the Cà ¡diz junta, Mexico exploded into crisis. The instability revealed acute  social divisions within Mexico. The upper classes sought to establish an autonomous government that would represent their interests, and the lower classes struggled against the dominance of the local elites.†Ã‚   (Kirkwood 75) There were many groups and each had their own list of grievances but they did have a few issues in common. One major criticism was Spain’s inability to govern Mexico properly. Another was the social identity change going on with the Mexicans. They were becoming proud of themselves as a people and changing the attitude that anything European was possibly superior. In 1810, the audiencia in Mexico City took power from Francisco Javier de Lizana y Beaumont. The audiencia was not any better at maintaing stability than any of the others and fearful of weak government leadership, semi-secret groups began meeting to discuss the nations future. To avoid detection, they disguised themselves as debate clubs or literary discussion groups. One such group was the Literary and Social Club of Querà ©taro, of which Father Hidalgo y Costilla was a member. â€Å"Noted as a defender of the downtrodden, well read, and with a capacity to forcibly express his ideas, he emerged as an important participant in the literary club in Querà ©taro.† (Kirkwood 79) It was due to these qualities and the encouragement he had shown the people regarding the creation of their own industries that Hidalgo y Costilla had become the leader of a revolution. Tired of the oppression of Spanish rule, he began planning for Mexico to gain its independence. â€Å"By 1810 Hidalgo's main energies were devoted to conspiring for an uprising that he hoped would lead to Mexican independence. The center of the conspiracy was the city of Querà ©taro, some fifty miles southeast of Dolores on the road to Mexico City. His fellow conspirators, also  criollos, planned to organize an insurrection and seize power from the peninsulares and their al lies. Initially, as a ruse, they would declare their fealty to King Ferdinand VII, but their clear final purpose was independence† (Smith 12,13) The government got word of the uprising and start arresting people who were suspected of participating. Hidalgo y Costilla was informed that this was happening and decided to take action. Racing to the church, he used the bells to call all the parishioners to him and proceeded to make a stirring speech against bad government known as the Grito de Dolores (Shout from Dolores). This speech described the situation and feeling in Mexico so aptly that it is considered the beginning moment of Mexico’s independence and made Hidalgo y Costilla a historical icon. Inspired by the Grito de Dolores, an army of 700 followed Hidalgo y Costilla on a march towards Guanajuato, by the time they were nearly there, the army had grown to almost 20,000 men. Despite his stirring speeches and large crowd of followers, Hidalgo y Costilla soon found he was in charge of an unruly mob rather than a trained army. They overtook the granary at Guanajuato and defeated the royalist soldiers but soon after Hidalgo y Costilla’s mob began destroying property, burning and pillaging and killing landowners and their families. â€Å"These excesses redoubled the resolve of the viceroy in Mexico City to put down the rebellion. Hidalgo and his military commanders were excommunicated, and royalist forces were raised to march north and engage Hidalgo's troops   (Smith 13) It was at this point that Hidalgo y Costilla made his biggest military mistake. He did not realize the forces guarding Mexico City were weak and unprepared. If he had marched on Mexico City and taken it, the war for independence would have been over at that point. Instead he and his mob headed to Queretaro, but when they were defeated, they retreated back to Guanajuato. Hidalgo y Costilla and his army tried to escape to the United States when a large, well trained royalist army appeared outside of Guanajuato, but they were captured before they could cross the border. Hidalgo was arrested, charged and found guilt of heresy and treason. He was also excommunicated by an ecclesiastical court. Now he was no longer considered a priest and was a traitor to the Spanish. â€Å"On the morning of July 30, 1811, the day after his degradation from th   priesthood, Hidalgo went before a firing squad in the courtyard of the former Jesuit College which had been his prison since April.† (Hamill 216) Despite the charges and his execution, Father Miguel Hidalgo y Costilla remains a hero to the people of Mexico. In Dolores, the Casa de Don Miguel Hidalgo, where he lived from 1804 to 1810, is full of furniture and document exhibits from that time. The Museo de la Independencia, or Independence Museum, has been converted from the old prison into a historical arts center. A larger than life bronze statue of Miguel Hidalgo graces the center of the park and all around Dolores are opportunities to purchase Talavera, a type of porcelain introduced by Father Hidalgo. Matamoros, Mexico boasts a main square featuring monuments to Hidalgo and others who lost their lives in the Mexican War of Independence. More tributes and monuments are found throughout Mexico, Texas and surrounding areas. Father Miguel Hidalgo y Costilla may not have been a war savvy general but his genuine concern for the plight of his people and his encouragement to fight for an independent Mexico has truly made him the â€Å"Father of Mexican Independence.† Works Cited Anderson, Geri. Dolores Hidalgo: Mexico’s Cradle of Independence. 2007. 7 Mar. 2007 Hamill, Hugh M. The Hidalgo Revolt: Prelude to Mexican Independence. Gainesville, FL: University of Florida Press, 1966. Questia. 5 Mar. 2007 . Kirkwood, Burton. The History of Mexico. Westport, CT: Greenwood Press, 2000. Questia. 5 Mar. 2007 . Smith, Clint E. Inevitable Partnership:   Understanding Mexico-U.S. Relations. Boulder, CO: Lynne Rienner, 2000. Questia. 6 Mar. 2007 .                                             

Business Policy advised to Sigma Global-Free-Samples-Myassignment

To: Mrs. Rania Singh, Customer Service Agent. Subject: To obey recommendations discussed in the memo The propaganda of this memorandum is to give an insight on the changes in the information provided to the future prospect for business. The change in policy will help in the betterment of the service provided by the organization to its clients. The agents of Sigma Global are advised to get approval of the material prepared for local marketing and advertising. As it is the most basic and initial projection of the organization to the local clients. Agents are warned and adhered to avoid unethical advertising and marketing to lure prospect clients. False information to the students will hampers relationship with the organization and is not acceptable at any cost. Agents should understand that we aim to guide the student and not to mislead them. It will result in Agents termination if found guilty of charge It had brought into our attention that our clients are finding it difficult to comprehend to the information on different services provided by the organization. To clear their misunderstanding it is necessary from our behalf to change the rules and policy to enlighten the student in a language that they would understand and comprehend best. Students are finding it difficult to understand the answer of few basic questions, which should have been clearly delta with by out agents. It is it important from our behalf to help the student choose the best university as per their need and preferences. To start with, agents should make the student comfortable and ask question regarding different aspect of their need and requirement. Agents should work on the soft skills and try to build repo with the student to understand their want. The inquiry should be conducted in a conversation manner so that it will make students comfortable and help them to easily interact and convey their requirement once that phase is cleared, the agent will now ask about the education qualification and would try to understand what the student want to pursue and from where. If the student have proper knowledge about the course and the institution he want to opt from the Agent will then ask related and relevant question to understand all the requirement o f the student and will try to suggest best alternative if needed. Agents are requested that student with no proper knowledge about courses and universities should be approached with calm and willing to help attitude as it will make them ease and help them open up. We want to make them understand that we are willing to help and shying away will hinder the process. Agents will ask these students about their aspiration and motivation and would try to figure the reason they want to study abroad. In addition, once the agent, relevant information about the course, understands it and university which will help accomplish the desired results should be provided. Agents are asked to provide information of the relevant universities and colleges offering the degree the student require as well as clear overview of all the other alternatives, the ranking of different universities as well as eligibility of different universities based on merit list should be made clear to the students from agents end.   Agents are requested to ask question about financial stability and source of income from students to help them acquire the best university and accommodation facility whilst their stay abroad. Agents are requested to represent all the universities and colleges in equal and fair manner to the students, so that it would look like as a choice given to the student to choose upon. It will give the versatility to the student to determine the place and the university he would like to opt. Agents are request to make students understand that studying aboard is all about practical implementation and usage of the education. It is equally important from student’s behalf to look into the different recreational activities and co-curricular prospects given by different universities and fun learning sessions provided by the universities. Agents are informed that it is necessary to understand the need of student’s requirement about the stay and the option we have and can provide to the s tudents. Accommodation advice to the student should be accurate and must be exactly as promised. It is important that the expectation that they will have about the accommodation met as per requirement or else it will hamper the after sale service which will again lose us prospective clients. Agents are requested to inform students about all the facilities that can be availed from the organization and it is important for the agents to advice the students taking admission in the distant universities and colleges about the transportation facility which can be availed by them from our organization. Agents should let the students know that we are providing a substantial amount to every student to help them start in the new country, which can be utilized for the transportation allowance. The initial transportation fee will be given special discount of 20% if booked with the full amount of admission fee and rest of the expenses. Agents are informed that students need assurance about the un iversity and the value of degree after completion of the course. It is necessary to provide proper information about placement cell and universities previous record of accomplishment agents should bring students attention about important rules and regulation, which needs to be mandated by the students in the country they will go for studies. Agents are warned again about providing false hopes, guarantee of permanent visa and work placement to attract the student is wrong practice, and Agent should avoid it. Honesty to build strong relationship with the students during the application process creates a transparency about the procedure. Honesty is a virtue and same is the motto of the organization so Agents should uphold companies values to its clients Olaleke, O.O., Taiye, T.T. and Olumide, E.O., 2014. Customer relationship management approach and student satisfaction in higher education marketing.  Journal of Competitiveness,  6(3). Stebleton, M.J., Soria, K.M. and Cherney, B.T., 2013. The high impact of education abroad: College students' engagement in international experiences and the development of intercultural competencies.  Frontiers: The Interdisciplinary Journal of Study Abroad,  22, pp.1-24. Taylor, C. and Robinson, C., 2014. 'What matters in the end is to act well': Student engagement and ethics. Hanson, V., Caputo, John S., & Caputo, Giovanni. (2015).  Studying Abroad: Adaptive Communication for Effective Intercultural Interactions,  ProQuest Dissertations and Theses. Nguyen, M. (2012). Vietnamese Students' Transitions in Study Abroad Programs.  Australian Journal of Career Development,  21(3), 13-22. Quick Tips for Students who want to Study Abroad. (2015, March 03).  UWIRE Text, p. 1. Highum, A. (2014).  Undergraduate Global Education: Issues for Faculty, Staff, and Students. New York: John Wiley & Sons, Incorporated. Zhuang, Weiling, King, Kristen, & Carnes, Lana. (2015). Studying Abroad: Understanding the Relationships among Beliefs, Perceived Value, and Behavioral Intentions.  Journal of Teaching in International Business,  26(1), 32-45.

Police Officers' Problems in the 21st Century Research Paper

Police Officers' Problems in the 21st Century - Research Paper Example Issues like international terrorism have become burning issues for the Police. The old model of policing has changed and the way the role of Police was perceived has changed too. Access to information, the changes in the way Police responded to the new situation, the pre-emptive strikes, immigration etc are some of the key issues which have created significant challenges for the police and other authorities. 9/11 was one of the events which changed many things and virtually shifted the existing paradigm for the security and policing methods. It not only exposed the vulnerabilities of the existing security and policing procedures but also provided an opportunity to look into the better ways to manage the risk and threat posed to the society by the negative elements. It is therefore critical to understand that the challenges and opportunities available to Police are unique in nature and need to be viewed from the perspective of the changes which have taken place since 9/11. The policing model and the resulting changes therefore need to be discussed in order to fully understand the practical origins of the challenges faced by the police during 21st century. This paper will therefore make an attempt to discuss the challenges faced by Police during 21st century while discussing the difference between the challenges faced by the Police in past.The original duty or the mission of Police, as outlined by Sir Robert Peel, is to prevent crime and disorder. however, the overall sensitivity and the responsibilities of Policies have radically changed in the wake of current situation. The founder of modern model for Policing, Sir Robert Peel outlined the basic duty of police to ensure the safety of the general public and the preservation of peace within an in creasingly pluralist society The police’s role is now not just limited to the prevention of crime at the community level however, it now also entails a broader scope for activities which are considered as essential for controlling and preventing terrorist activities. The traditional community policing model was based on gaining and developing the trust within the public to achieve the overall aim of public safety. This model therefore required a closer link with the community to continuously look for information and intelligence which cannot help to prevent the crime but also allow the police to track down those who committed the crimes. (Bayley and Shearing) The shift towards intelligence led policing from the traditional investigative and reactive policing approach and than to the more pro-active military like policing model has been due to the changing nature of crime. As mentioned above that with the war on terrorism and the change in the way society face internal and ext ernal threats, the role of policing and the approaches of policing have changed. The above changes in the way society now perceives the role of Police and other law enforcement agencies therefore suggest that Police may face significant challenges during 21st Century. Counter-terrorism One of the most important challenges to be faced by the Police during 21st century is the counter- terrorism and anti-terrorism. The events of 9/11 have changed the way security was generally perceived by the societies. The increasing threat to the life and property of innocent citizens and the State itself therefore necessitated that the traditional role of Police should change. Earlier the significant challenge faced by the Police was to keep the criminals in check while ensuring that the general environment of peace and harmony exists in society. However, the anti-terrorism has forced police to face the significant challenge of meeting the new requirements. (Cooley) Terrorism has emerged as a pheno menon

Diversity & inclusion Research Paper Example | Topics and Well Written Essays - 1250 words

Diversity & inclusion - Research Paper Example American legislation has shown progressive development in the past few decades when it comes to children with special needs. One of the major transformations taken by legislation was from The Education for All Handicapped Children act to Individuals with Disabilities Education Act. All these changes and development have ensured that individuals with special needs are provided with all the necessary support they require from society and state in order to have access to appropriate education. The main focus of this law is to ensure that special emphasis is put on individuals instead of their disability and state provides them with all the sources required for education either in a public schools or any other facility under individualized education programs. These individualized programs require extensive evaluation in order to ascertain disability of the child, and referrals of IEP teams. According to Gargiulo (2006), "The journey from referral to assessment to the development of an IE P and eventual placement in the most appropriate environment is a comprehensive process incorporating many different phases (p. 59). All these phases are outlined by IDEA (2004) and have been made broader in order to include needs of children with disability, their parents and teachers with a goal to ensure that these children have all the opportunities to acquire education from the inception. 2. Key Components of ‘The Education for All Handicapped Children Act (PL 94-142) 1975’ ... b) Non-discriminatory Identification and Evaluation With the help of this clause, necessary protection was provided to children with culturally and linguistically diverse backgrounds. The mandate ensured that misidentification of students with special needs is refrained and placement of children in special education programs is just. For this purpose, assessment is performed in child’s primary language, conducted by qualified professionals, customized to examine specific areas requiring attention, consist of at least two procedures, should reflect non-discrimination against any disability and a multidisciplinary team proficient in child’s disability is involved in the administration of this assessment (â€Å"Current Legislation†, n.d). c) Individualized Education Program (IEP) An education program should be designed for children with identified disability with the help of a team called IEP team (comprising of professionals, parents and other personnel) who would annually develop or update such programs (â€Å"Current Legislation†, n.d). d) Least Restrictive Environment This provision indicates that necessary effort should be made to ensure that children who are disabled should be educated with children having no disability until unless this educational setting does not meet the needs of every child. e) Due Process This mandate allows parents to contest educational provisions and disability programs designed for their children. Hence, multiple rights are provided to parents for reviewing educational provisions before and after placement of their child. f) Parental Participation This mandate allows parents to participate in placement and IEP development along with evaluation regarding children’s progress